Jorge Maícas Royo, Gareth Leng and Duncan J. MacGregor
Presented at tthe International Congress on Neuroendocrinology, Toronto 2018
In rodents and in some but not all other mammals, oxytocin responds to plasma osmotic pressure and blood volume to regulate sodium excretion at the kidneys. Oxytocin neurones respond to increases in plasma osmotic pressure partly as a result of intrinsic osmosensitivity, but also as a result of increased afferent input arising directly and indirectly from osmoreceptors in other forebrain regions. Experiments generate an osmotic challenge by injecting or infusing NaCl.
Here we present a previous computational model integrated with a new one that simulates the [Na+] dynamics in the body. To test the full model we have matched different experimental data from rats under hypertonic and hypovolemic challenges.